ISOM LAB

The Isom Lab is a research group in the Department of Pharmacology at the University of Michigan Medical School. We study the role of voltage-gated sodium channels in inherited disease, including epileptic encephalopathy and cardiac arrhythmia. Our expertise includes the study of human induced pluripotent stem cell neurons and cardiac myocytes as well as transgenic mouse models using electrophysiology, confocal imaging, and molecular and cell biological techniques.

Latest News

Research

Mutations in ion channels can lead to neurological or cardiovascular diseases called channelopathies. Our work focuses on mutations in genes encoding voltage-gated sodium channel α and β subunits that lead to a devastating pediatric epileptic encephalopathy called Dravet syndrome, a disease with a high risk of Sudden Unexpected Death in Epilepsy (SUDEP). We have proposed that SUDEP arises from simultaneous arrhythmias of brain and heart due to the expression of mutant sodium channel genes in both organs.  Our ultimate goals are to discover novel targets for epilepsy therapeutics and to identify biomarkers for SUDEP risk.

Group Members

Lori L. Isom, PhD

Lori L. Isom, PhD

Chair, Department of Pharmacology
Maurice H. Seevers Collegiate Professor of Pharmacology
Professor of Molecular and Integrative Physiology
Professor of Neurology
Charles (Kachi) Anumonwo

Charles (Kachi) Anumonwo

Research Technician
Veronica Beck

Veronica Beck

Graduate Student, Neuroscience Program
Allie Bouza

Allie Bouza

Pharmacology Graduate Student
Angela N. Carter, PhD

Angela N. Carter, PhD

NINDS Postdoctoral Fellow
Chunling Chen

Chunling Chen

Senior Research Associate
Krisyah T. Clemons

Krisyah T. Clemons

Summer Researcher from Spelman College
Nick Denomme

Nick Denomme

Pharmacology Master’s Student
Nnamdi Edokobi

Nnamdi Edokobi

Pharmacology Graduate Student
Rene Caballero Floran, PhD

Rene Caballero Floran, PhD

Postdoctoral Fellow
Chad Frasier, PhD

Chad Frasier, PhD

Research Investigator, Department of Pharmacology
Jacob Hull

Jacob Hull

Graduate Student, Neuroscience Program
Chante Liu

Chante Liu

Research Technician Associate
Luis Lopez-Santiago, PhD

Luis Lopez-Santiago, PhD

Assistant Research Scientist, Pharmacology, Medical School

lopezslf@umich.edu

James Offord, PhD

James Offord, PhD

Research Assistant Professor of Pharmacology
Heather O’Malley, PhD

Heather O’Malley, PhD

Research Investigator, Department of Pharmacology
Kaylin White

Kaylin White

Pharmacology Graduate Student

kaymw@umich.edu

Yukun Yuan, PhD

Yukun Yuan, PhD

Research Assistant Professor of Pharmacology
Yanting Zhao, PhD

Yanting Zhao, PhD

Research Investigator, Department of Pharmacology

Select Publications

Click here to view Lori Isom’s publications on PubMed.

Click here to view Lori Isom’s publications on Google Scholar.

Lopez-Santiago LF, Yuan Y, Wagnon JL, Hull JM, Frasier CR, O’Malley HA, Meisler MH, Isom LL. Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathyl. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2383-2388.

Read the publication.

Bao Y, Willis BC, Frasier CR, Lopez-Santiago LF, Lin X, Ramos-Mondragón R, Auerbach DS, Chen C, Wang Z, Anumonwo J, Valdivia HH, Delmar M, Jalife J, Isom LL. Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.
Circ Arrhythm Electrophysiol. 2016 Dec;9(12). pii: e003923.

Read the publication.

Frasier CR, Wagnon JL, Bao YO, McVeigh LG, Lopez-Santiago LF, Meisler MH, Isom LL. Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy. Proc Natl Acad Sci U S A. 2016 Oct 26; 113(45): 12838–12843.

Read the publication.

Open Positions

POSTDOCTORAL FELLOWS
There are currently no open postdoctoral positions open.

GRADUATE STUDENTS
The lab belongs to several Michigan Ph.D. programs, including Pharmacology, Neuroscience, CMB, and Molecular and Integrative Physiology, and may accept rotation students at any time of year. Please e-mail Lori lisom@umich.edu to discuss a possible rotation. Advance notice (one month or more) is preferred.

UNDERGRADUATES
Please send an e-mail with a short note about your interest in our lab, your CV, and a transcript to Lori at lisom@umich.edu.

STAFF
There are currently no open staff positions in the lab.

Photos

Contact

Isom Laboratory
Department of Pharmacology
University of Michigan Medical School

2301E MSRB III (office)
2200 MSRB III (lab)
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5632

734-936-3050 (office)
734-936-3043 (lab)

Department of Pharmacology Website: https://medicine.umich.edu/dept/pharmacology

If you’d prefer to contact the Isom Lab via email, please use the contact form below.

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