Welcome to the Isom Lab, established in 1995, in the Department of Pharmacology at Michigan Medicine. Our goal is to make Sudden Unexpected Death in Epilepsy (SUDEP) history by studying gene variants linked to developmental and epileptic encephalopathy, especially variants in genes encoding voltage-gated sodium channels. Our work uses human induced pluripotent stem cell neurons and cardiac myocytes as well as transgenic mouse and rabbit models. Our expertise includes electrophysiology, confocal imaging, genetics, and molecular and cellular biology techniques.

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Research

Variants in ion channel genes can lead to neurological or cardiovascular diseases called channelopathies. Our work focuses on human variants in genes encoding voltage-gated sodium channel α and β subunits that lead to a devastating pediatric epileptic encephalopathy called Dravet syndrome, a disease with a high risk of Sudden Unexpected Death in Epilepsy (SUDEP). We have proposed that SUDEP arises from simultaneous arrhythmias of brain and heart due to the expression of mutant sodium channel genes in both organs.  Our ultimate goals are to discover novel targets for epilepsy therapeutics and to identify biomarkers for SUDEP risk.

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Isom Lab Members

Relentless in the pursuit of new cures

Lori L. Isom, PhD

Lori L. Isom, PhD

Chair, Department of Pharmacology, Maurice H. Seevers Collegiate Professor of Pharmacology, Professor of Molecular and Integrative Physiology, Professor of Neurology
Vikram Bagshi

Vikram Bagshi

MSTP Student
Shreeya Bakshi

Shreeya Bakshi

Graduate Student, Department of Pharmacology
Sabrina Bramson

Sabrina Bramson

Undergraduate Researcher, Department of Pharmacology
Sebastian Casillas-Lopez

Sebastian Casillas-Lopez

UROP Student
Amanda Catalfio, PhD

Amanda Catalfio, PhD

Postdoctoral Fellow, Pharmacology
Stephanie Chan

Stephanie Chan

Undergraduate Research Assistant
Chunling Chen, MD

Chunling Chen, MD

Assistant Research Scientist, Department of Pharmacology
Yan Chen

Yan Chen

Research Lab Specialist Senior, Department of Pharmacology
Yang Chen

Yang Chen

Master’s Degree Student, Department of Pharmacology
Krystal Santiago Colon

Krystal Santiago Colon

Graduate student, Department of Pharmacology
Rene Caballero Floran, PhD

Rene Caballero Floran, PhD

Research Investigator, Department of Pharmacology
Karl Habig

Karl Habig

Research Technician, Department of Pharmacology
Daniel Kashima, MD, PhD

Daniel Kashima, MD, PhD

Child Neurology Resident

kashinmad@med.umich.edu

Qinghua Liu, PhD

Qinghua Liu, PhD

Visiting Faculty Member: Associate Professor Key Laboratory of Cellular Physiology of Ministry of Education Department of Pathophysiology Shanxi Medical University

qingliu@med.umich.edu

Luis Lopez-Santiago, PhD

Luis Lopez-Santiago, PhD

Associate Research Scientist, Department of Pharmacology

lopezslf@umich.edu

Dyke P. McEwen, PhD

Dyke P. McEwen, PhD

Research Lab Specialist Senior, Department of Pharmacology

dmcewen@umich.edu

Heather O’Malley, PhD

Heather O’Malley, PhD

Assistant Research Scientist, Department of Pharmacology
Chloe Moore

Chloe Moore

Undergraduate Researcher, Department of Pharmacology
Roberto Ramos Mondragon, PhD

Roberto Ramos Mondragon, PhD

Research Assistant Professor, Department of Pharmacology
Shuyun Wang, MD, PhD

Shuyun Wang, MD, PhD

Research Lab Specialist Senior, Department of Pharmacology

wangshuy@med.umich.edu

Yukun Yuan, MD, PhD

Yukun Yuan, MD, PhD

Associate Research Scientist, Department of Pharmacology

Publications

Click here to view Lori Isom’s publications on PubMed.

Click here to view Lori Isom’s publications on Google Scholar.

Open Positions

POSTDOCTORAL FELLOWS

GRADUATE STUDENTS
Dr. Isom belongs to several Michigan Ph.D. training programs, including Pharmacology, Neuroscience, CMB, and Molecular and Integrative Physiology. If interested in a research rotation, please send her an e-mail at lisom@umich.edu.

UNDERGRADUATES
Please send an e-mail with a short note about your interest in our lab, your CV, and a transcript to Dr. Isom at lisom@umich.edu.

STAFF

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Contact

Isom Laboratory
Department of Pharmacology
University of Michigan Medical School

2301E MSRB III (office)
2200 MSRB III (lab)
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5632

734-936-3050 (office)
734-936-3043 (lab)

Department of Pharmacology Website: https://medicine.umich.edu/dept/pharmacology

If you’d prefer to contact the Isom Lab via email, please use the contact form below.

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