Isom Lab | The University of Michigan at Ann Arbor

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Welcome to the Isom Lab, established in 1995, in the Department of Pharmacology at Michigan Medicine. Our goal is to make Sudden Unexpected Death in Epilepsy (SUDEP) history by studying gene variants linked to developmental and epileptic encephalopathy, especially variants in genes encoding voltage-gated sodium channels. Our work uses human induced pluripotent stem cell neurons and cardiac myocytes as well as transgenic mouse and rabbit models. Our expertise includes electrophysiology, confocal imaging, genetics, and molecular and cellular biology techniques.

Dr. Isom elected to the National Academy of Medicine

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December 13, 2022

Dr. Isom receives the 2023 Basic Science Award from the American Epilepsy Society

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December 13, 2022

Isom Lab Celebrates at the 2023 AES Meeting in Nashville!

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December 13, 2022

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Research

Variants in ion channel genes can lead to neurological or cardiovascular diseases called channelopathies. Our work focuses on human variants in genes encoding voltage-gated sodium channel α and β subunits that lead to a devastating pediatric epileptic encephalopathy called Dravet syndrome, a disease with a high risk of Sudden Unexpected Death in Epilepsy (SUDEP). We have proposed that SUDEP arises from simultaneous arrhythmias of brain and heart due to the expression of mutant sodium channel genes in both organs. Our ultimate goals are to discover novel targets for epilepsy therapeutics and to identify biomarkers for SUDEP risk.

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Group Members

Lori L. Isom, PhD

Chair, Department of Pharmacology, Maurice H. Seevers Collegiate Professor of Pharmacology, Professor of Molecular and Integrative Physiology, Professor of Neurology

lisom@umich.edu

Shreeya Bakshi

Graduate Student, Department of Pharmacology

sbakshi@umich.edu

Sabrina Bramson

Undergraduate Researcher, Department of Pharmacology

sbramson@umich.edu

Chunling Chen, MD

Assistant Research Scientist, Department of Pharmacology

chunling@umich.edu

Yan Chen

Research Lab Specialist Senior, Department of Pharmacology

chenyan@umich.edu

Krystal Santiago Colon

Graduate student, Department of Pharmacology

ksantia@umich.edu

Rene Caballero Floran, PhD

Research Investigator, Department of Pharmacology

renecaba@umich.edu

Karl Habig

Research Technician, Department of Pharmacology

khabig@med.umich.edu

Samantha Hodges, PhD

Michigan Postdoctoral Pioneer Program Fellow, Departments of Pharmacology and Neurology

hodgesam@umich.edu

Luis Lopez-Santiago, PhD

Associate Research Scientist, Department of Pharmacology

lopezslf@umich.edu

Dyke P. McEwen, PhD

Research Lab Specialist Senior, Department of Pharmacology

dmcewen@umich.edu

Joe Minton, MS

Research Technician, Department of Pharmacology

jcminton@umich.edu

Heather O’Malley, PhD

Assistant Research Scientist, Department of Pharmacology

homalley@umich.edu

Chloe Moore

Undergraduate Researcher, Department of Pharmacology

chloemoo@umich.edu

Roberto Ramos Mondragon, PhD

Research Investigator, Department of Pharmacology

robramos@med.umich.edu

Caroline Scheuing

Undergraduate Researcher, Department of Pharmacology

cesc@umich.edu

Shuyun Wang, MD, PhD

Research Lab Specialist Senior, Department of Pharmacology

wangshuy@med.umich.edu

Yukun Yuan, MD, PhD

Associate Research Scientist, Department of Pharmacology

yukuny@umich.edu

Publications

Click here to view Lori Isom’s publications on PubMed.

To access our new Science Translational Medicine paper with Stoke Therapeutics. “Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome,” please click on the following links:

Reprint: http://stm.sciencemag.org/cgi/rapidpdf/12/558/eaaz6100?ijkey=N5jj5tKEmu0oY&keytype=ref&siteid=scitransmed

Full text: http://stm.sciencemag.org/cgi/content/full/12/558/eaaz6100?ijkey=N5jj5tKEmu0oY&keytype=ref&siteid=scitransmed

Click here to view Lori Isom’s publications on Google Scholar.

Open Positions

POSTDOCTORAL FELLOWS
We are currently searching for postdoctoral fellows with expertise in patch clamp electrophysiology who are interested in working with mouse models of neurological or cardiac disease. If interested, please send Dr. Isom an e-mail at lisom@umich.edu.

GRADUATE STUDENTS
Dr. Isom belongs to several Michigan Ph.D. training programs, including Pharmacology, Neuroscience, CMB, and Molecular and Integrative Physiology. If interested in a research rotation, please send her an e-mail at lisom@umich.edu.

UNDERGRADUATES
Please send an e-mail with a short note about your interest in our lab, your CV, and a transcript to Dr. Isom at lisom@umich.edu.

STAFF
We currently have an open technical position for a person with expertise in histology/immunohistochemistry. If interested, please send Dr. Isom an e-mail at lisom@umich.edu.

Photos

Contact

Isom Laboratory
Department of Pharmacology
University of Michigan Medical School

2301E MSRB III (office)
2200 MSRB III (lab)
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5632

734-936-3050 (office)
734-936-3043 (lab)

Department of Pharmacology Website: https://medicine.umich.edu/dept/pharmacology

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Funding Partners

Lori L. Isom, PhD

Shreeya Bakshi

Sabrina Bramson

Chunling Chen, MD

Yan Chen

Krystal Santiago Colon

Rene Caballero Floran, PhD

Karl Habig

Samantha Hodges, PhD

Luis Lopez-Santiago, PhD

Dyke P. McEwen, PhD

Joe Minton, MS

Heather O’Malley, PhD

Chloe Moore

Roberto Ramos Mondragon, PhD

Caroline Scheuing

Shuyun Wang, MD, PhD

Yukun Yuan, MD, PhD

If you’d prefer to contact the Isom Lab via email, please use the contact form below.